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Mechanistic plausibility does not establish the magnitude, consistency or durability of a visible clinical effect

doi: 10.1056/NEJMoa1603827 38 PfefferMAClaggettBDiazRDicksteinKGersteinHCKberLVet al

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The STEP-1 data showing superior weight loss outcomes versus lifestyle intervention alone strengthened the medical necessity arguments used in Florida insurance appeals